Spor-Mo-Metrics – Our Movember Team
Published: December 12th, 2011
Revised: December 12th, 2011
This year three of our staff joined the international ranks of Mo Bros and Mo Sistas to raise money and awareness for men’s health. Our Spor-Mo-Metrics team consisting of A ”mean stache” Maharaj; Mike “the handle-bar” Saleh, and “Yor-de-cutest Mo Sista” Guardiola raised over $1000 for Prostate Canada. Congratulations to all the Movember participants and supporters across the globe who raised over $110 million of vital funds and awareness for men’s health, specifically prostate cancer. A special congratulations to our client Stantec, lead by Steve Fulford, who by raising over $122k climbed the team leader board to #3 in Canada.
Gut microbiota diversity and atopic disease: does breastfeeding play a role?
Published: December 8th, 2011
Revised: July 21st, 2014
Background
It is debated whether a low total diversity of the gut microbiota in early childhood is more important than an altered prevalence of particular bacterial species for the increasing incidence of allergic disease. The advent of powerful, cultivation-free molecular methods makes it possible to characterize the total microbiome down to the genus level in large cohorts.
Objective
We sought to assess microbial diversity and characterize the dominant bacteria in stool during the first year of life in relation to atopic eczema development.
Methods
Microbial diversity and composition were analyzed with barcoded 16S rDNA 454-pyrosequencing in stool samples at 1 week, 1 month, and 12 months of age in 20 infants with IgE-associated eczema and 20 infants without any allergic manifestation until 2 years of age (ClinicalTrials.gov ID NCT01285830).
Results
Infants with IgE-associated eczema had a lower diversity of the total microbiota at 1 month (P = .004) and a lower diversity of the bacterial phylum Bacteroidetes and the genus Bacteroides at 1 month (P = .02 and P = .01) and the phylum Proteobacteria at 12 months of age (P = .02). The microbiota was less uniform at 1 month than at 12 months of age, with a high interindividual variability. At 12 months, when the microbiota had stabilized, Proteobacteria, comprising gram-negative organisms, were more abundant in infants without allergic manifestation (Empirical Analysis of Digital Gene Expression in R [edgeR] test: P = .008, q = 0.02).
Conclusion
Low intestinal microbial diversity during the first month of life was associated with subsequent atopic eczema.
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